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DATAR – trublood

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DATAR - trublood

BIOPSY ALLOWANCE

Trublood was developed by Datar Cancer Genetics based on the results of several clinical studies and validated in more than 40,000 samples. These included samples from asymptomatic subjects undergoing screening tests such as mammograms, colonoscopies, PAP smears, serum CA markers and other clinical tests, as well as more than 17,000 samples from patients with various types of cancer and patients with benign diseases.

trublood is particularly recommended for:

...symptomatic individuals in whom it is difficult to biopsy the tissue.

...patients in whom standard procedures (imaging, biopsy) have failed or are inconsistent with clinical observations.

No queues

Results in 10-14 days

Only a blood test is needed

Experienced specialists

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About the trublood test

  • Tumours release thousands of cells into the bloodstream, where circulating tumour cells (CTCs) survive for about 1 to 2.5 hours.
  • In order to detach from the primary tumour and spread into the blood, the cells must undergo a cellular process known as epithelial-mesenchymal transition (EMT).
  • EMT increases the migratory capacity of tumour cells, allowing cells to penetrate the vascular system and circulate as single or clusters of circulating tumour cells.
  • CTCs exit the bloodstream after undergoing a reverse process called mesenchymal-epithelial transition (MET) and are able to colonise distant organs.
  • CTCs are defined as EpCAM (+), PanCK (+), CD45 (-) cells. Circulating tumour-associated cells (C-TACs) are defined as EpCAM (+), PanCK (+), CD45 (+/-) cells of tumour origin in the peripheral blood.
  • Non-tumour cells in the peripheral blood have a functional apoptotic mechanism, but CTCs and C-TACs are resistant to apoptosis.
  • An epigenetically active stabilisation process can eliminate normal cells and allow apoptosis-resistant CTCs and C-TACs to survive.
  • Sufficient C-TACs can be enriched and obtained for immunocytochemical (ICC) profiling with markers used in immunohistochemistry (IHC), which helps in the histopathological subtyping of tumour tissue.
  • To increase the sensitivity of the method, circulating free DNA (cfDNA) is tested at the same time. In very rare cases, no CTCs can be found, but cfDNA can be detected, leading to a positive result. However, cfDNA alone cannot provide any information as to the origin of the tumour disease.

Frequently asked questions

What is the clinical relevance of Trublood?
To date, 6 clinical studies involving more than 40,000 individuals have been published on Trublood and early cancer detection.

How is the analysis carried out and which analysts are involved?
Circulating tumour cells (CTCs/C-ETACs) and nucleic acids (ctDNA) are isolated and thoroughly analysed.

Trublood is available for the following organs:
– Breast
– CNS (central nervous system)
– Colon and rectum
– Lung
– Pancreatobiliary
– Prostate

Is Trublood useful in the following cases?
– Can Trublood distinguish between adenocarcinoma and squamous cell carcinoma? YES
– Can Trublood determine the tumour stage? NO
– Can Trublood be used in haematological malignancies? NO
– Can CTCs be found in blood in carcinomas in situ? Up to 3 million CTCs can be found in the blood in carcinoma in situ.

Crystal, medical centre, d.o.o.

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Štukljeva cesta 46, 1000 Ljubljana
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01 235 50 20
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info@crystalmc.si
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Andrej

Treatment of joint pain with mesenchymal stromal stem cells

“I have suffered from chronic joint pain, especially in my knees, for several years. Traditional treatments such as physical therapy, painkillers and even corticosteroid injections have only provided temporary relief. Desperate for a more permanent solution, I started researching alternative treatments and came across mesenchymal stem/stromal cell (MSC) therapy. After consulting my doctor and doing extensive research, I decided to give it a try.

The treatment process was simple and professionally managed. The first consultation included a thorough assessment of my condition and detailed information on how MSC therapy works. The procedure itself was minimally invasive and surprisingly quick.

What surprised me most was the gradual but noticeable improvement in my condition. Within a few weeks I felt significant pain relief and increased mobility. Tasks that had become difficult or impossible, such as walking up stairs, lifting objects and even walking for long periods of time, became much easier. The stiffness and constant pain that had plagued me for years were greatly reduced. Three months after treatment, I can say with certainty that the improvement has been remarkable. The quality of my life has improved significantly.

I highly recommend MSC therapy to anyone who suffers from chronic joint pain. It has been a game changer for me, providing long term relief where other treatments have failed. The professionalism and care of the medical team (Crystal?) combined with the innovation of the treatment made for an exceptional experience. If you are considering this option, I would recommend that you consult with a qualified healthcare professional to determine whether MSC therapy could be the solution you have been looking for. “

Milena

Stem cell therapy for arthrosis of the fingers of the hand

“My name is Milena and I am happy to share my experience of stem cell therapy for Heberden’s and Bouchard’s osteoarthritis of the toes. For years I have been struggling with unbearable pain and swelling in most of my fingers, but especially in three of them, which has affected my daily life.
After extensive research and consultations, I was advised by rheumatologists that medicine has no cure for small joint diseases and that I can only relieve them with painkillers. So I decided to try stem cell therapy. In the procedure, stem cells were injected into each joint of the fingers of both hands. The procedure went smoothly and professionally, but also with not too much pain.

The results were great. I noticed a significant reduction in swelling and pain in a short time. Gradually, the mobility of my fingers improved to some extent, but most importantly, I no longer woke up at night in pain, I no longer had to take painkillers and I was able to do everyday tasks again, including gardening.
Stem cell therapy has made my life easier and, above all, it has eliminated the need to take painkillers, which in the long run also have side effects. I am immensely grateful for the advances in medical science that have made this possible and for the skilled professionals who have guided the treatment. If you suffer from osteoarthritis, I recommend that you opt for stem cell therapy.”

Katarina

Stem cell therapy for knee arthritis
“I was struggling with knee problems. My GP referred me for a check-up and I was diagnosed with arthritis, which required treatment. The only solution was surgery, but I had to wait several months for the procedure. During this time, I would have to take strong painkillers on a daily basis. I did not want to have surgery myself, as I had already had two hip operations, which took a very long time to recover from, and I did not like that, as I am a person who enjoys an active life.
When I started researching alternatives, I first heard about prp therapy, but I quickly learned that it would probably not work in my case. I continued my search and came across GaiaCell, where they produce advanced mesenchymal stem cell therapies, which are then used in treatment by specialists at Crystal MC. I decided to have a consultation at Crystal Medical Centre, where I was warmly welcomed by an orthopaedic surgeon and given a thorough examination. They assessed that MSCs could be a viable solution to my problems, suggested a treatment plan and the amount of cells I needed. I was advised to take my time to think things over, as the cost of the therapy as a pensioner did not seem small to me at first. After thinking it over, I decided to give it a try, thinking that if the stem cells didn’t help, I could always go ahead with the surgery.
I called them and they quickly confirmed the appointment. GaiaCell and Crystal Medical Centre are very responsive, flexible and fast – exactly what patients want. The orthopaedic surgeon explained everything in detail before the procedure, which gave me a lot of confidence. The procedure itself was calm and I didn’t feel too scared. After the procedure, I was warned that there might be mild swelling and that I needed to rest, and I did so. Even though I was no longer in pain and would have liked to go for a long walk, I made sure to listen to the advice of the experts.
It has now been two months and I no longer have any pain in my knee. If I could go back, I would do it again. I would advise anyone who has similar problems to consult Crystal – they will honestly explain all the options you have, assess your condition and suggest the amount of stem cells. For any concerns, they explain everything to you in detail and assess realistic therapy options. It is true that the therapy is self-pay, but the staff explained to me why the price is that way and that they try to keep the price as low as possible to make the therapies available to a wider range of people. Now that I look back, the price is really not that high compared to avoiding surgery, as I already felt a lot of relief after the therapy.
Thank you, GaiaCell and Crystal, for your professional approach and great experience. “